A bioassay,thrombin time(TT),method was developed for determining r-hirudin(rH)in urine and bile of rabbits so as to provide a methodology for further studying rH urinary and biliary excretion pharmacokinetics.
建立了一种生物测定法---凝血酶时间法(TT法)以测定家兔尿液及胆汁中的r-水蛭素(r-Hirudin,rH),从而为rH的排泄动力学研究提供测定方法学。