Both disorders are caused by mutations in the cartilage oligomeric matrix protein(COMP).
假性软骨发育不全(pseudoachondroplasia,PSACH)和多发性骨骺发育不良(multiple epiphyseal dysplasia,MED)均为骨发育不良性疾病的家族成员之一,它们的遗传方式和临床表型都具有异质性的特点,二者均由软骨低聚物基质蛋白(cartilage oligomeric matrix protein,COMP)基因突变所致。
Dynamic Monte Carlo simulation of inhibiting protein aggregation by polymer;
高分子抑制蛋白质聚集的动态Monte Carlo模拟
The effects of molecular chaperones, protein aggregation and macromolecular crowding on protein folding have been studied.
研究了细胞内存在的分子伴侣、蛋白质聚集和大分子拥挤环境对蛋白质折叠的影响。
However,scientists have know little about the mechanisms and details about the early steps of the protein aggregation,althought great efforts have been made,both in experiments and theories.
引起人们特别关注的是哪些疾病和哪些特定蛋白质有关,这些蛋白质的结构是怎么样的?蛋白质的结构是怎么样影响器官的功能?目前人们也发现和淀粉样疾病无关的蛋白质聚集也可以破坏细胞的功能。